Zotsatira za kafukufuku watsopano wofalitsidwa mu nyuzipepala ya Biomed Central BMC inasonyeza kuti chotsitsa cha turmeric chinali chothandiza ngati paracetamol pochepetsa ululu ndi zizindikiro zina za bondo osteoarthritis (OA).Kafukufukuyu adawonetsa kuti gulu la bioavailable linali lothandiza kwambiri pochepetsa kutupa.
Osteoarthritis ndi matenda osokonekera a mafupa a articular omwe amadziwika ndi kuwonongeka kwa cartilage, kugwirizana kwa mafupa, mitsempha, ndi fupa la pansi.Zizindikiro zodziwika bwino za osteoarthritis ndi kuuma ndi kupweteka.
Motsogozedwa ndi Shuba Singhal, PhD, kafukufuku wachipatala wosadziwika bwino, woyendetsedwa bwino adachitidwa ku Dipatimenti ya Orthopedics ya Lok Nayak Jai Prakash Hospital / Maulana Azad Medical College, New Delhi.Pa phunziroli, odwala 193 omwe adapezeka ndi matenda a nyamakazi a bondo adasinthidwa mwachisawawa kuti alandire turmeric extract (BCM-95) ngati capsule ya 500 mg kawiri tsiku lililonse, kapena piritsi ya 650 mg ya paracetamol katatu tsiku lililonse kwa milungu isanu ndi umodzi.
Zizindikiro za nyamakazi ya m'mabondo za ululu, kuuma kwamagulu, komanso kuchepa kwa magwiridwe antchito amthupi adawunikidwa pogwiritsa ntchito Western Ontario ndi McMaster Universities Osteoarthritis Index (WOMAC).Pambuyo pa milungu isanu ndi umodzi ya chithandizo, kusanthula kwa oyankha kunawonetsa kusintha kwakukulu kwa kuchuluka kwa WOMAC pazigawo zonse zofananira ndi gulu la paracetamol, ndi 18% ya gulu la BCM-95 likunena za kusintha kwa 50%, ndi 3% ya maphunziro omwe akuwonetsa kusintha kwa 70%.
Zotsatirazi zinawonetsedwa bwino m'magulu a BCM-95 a seramu yotupa: Miyezo ya CRP inachepetsedwa ndi 37.21%, ndipo ma TNF-α adadulidwa ndi 74.81%, kusonyeza kuti BCM-95 inachita bwino kuposa paracetamol.
Kafukufukuyu anali kutsatira kafukufuku wa Arjuna yemwe adachitika chaka chapitacho chomwe chinawonetsa kulumikizana kwabwino pakati pa mapangidwe ake amtundu wa curcumin ndi chisamaliro cha osteoarthritic.
"Cholinga cha kafukufuku wamakono chinali kumanga pa maphunziro oyambirira kuti apereke kumveka bwino komanso kumveka bwino pophatikizapo zolemba zambiri komanso njira yabwino yopangira zigoli," adatero Benny Antony, wotsogolera wothandizira wa Arjuna."Mphamvu ya anti-arthritic ya BCM-95 mu osteoarthritis imatheka chifukwa cha mphamvu yake yosinthira zolembera za TNF ndi CRP."
Knee OA ndiye chomwe chimayambitsa kulumala ndi ululu pakati pa anthu akuluakulu ndi okalamba.Pafupifupi 10 mpaka 15% mwa akuluakulu onse opitirira zaka 60 ali ndi mlingo wina wa OA, ndipo kufalikira kwakukulu pakati pa amayi kuposa amuna.
"Kafukufukuyu akutsimikiziranso mphamvu ya anti-arthritic ya BCM-95 ndipo amapereka chiyembekezo chatsopano kwa anthu mamiliyoni ambiri kuti asinthe moyo wawo," atero a Nipen Lavingia, mlangizi waukadaulo wa Arjuna Natural wokhala ku Dallas, TX.
"Tikuphunzira zambiri za njira zomwe curcumin's anti-inflammatory effect timakhulupirira kuti ndi zotsatira za mphamvu yake yoletsa zizindikiro zoyambitsa kutupa, monga prostaglandins, leukotrienes, ndi cyclooxygenase-2.Kuphatikiza apo, curcumin yawonetsedwa kuti imapondereza ma cytokines angapo otupa komanso oyimira kumasulidwa kwawo, monga tumor necrosis factor-α (TNF-α), IL-1, IL-8, ndi nitric oxide synthase, "adatero Antony.
Kuphatikizika kwapadera kwa BCM-95 kwa ma curcuminoids ndi mafuta ofunikira okhala ndi turmerone kumapambana zovuta za curcumin za bioavailability chifukwa cha chikhalidwe chake chokhala ndi lipophilic.
Nthawi yotumiza: Apr-12-2021