Curcumin Iwonetsedwa Kuti Ipititse Patsogolo Zoyeserera za Serum

Zotsatira za kafukufuku watsopano wofalitsidwa munyuzipepala ya Biomed Central BMC idawonetsa kuti turmeric yotulutsa inali yothandiza ngati paracetamol pochepetsa kupweteka ndi zizindikilo zina za bondo osteoarthritis (OA). Kafukufukuyu adawonetsa kuti zinthu zomwe sizikupezeka ndizothandiza kwambiri pakuchepetsa kutupa.

Osteoarthritis ndi matenda osachiritsika am'malo olumikizana ndi mafupa omwe amadziwika ndi kuwonongeka kwa karoti, zolumikizira zolumikizana, mitsempha, ndi mafupa apansi. Mawonekedwe wamba a nyamakazi ndi kuuma ndi kupweteka.

Wotsogozedwa ndi Shuba Singhal, PhD, kafukufukuyu wopangidwa mosadukiza adachitika ku department of Orthopedics ya Lok Nayak Jai Prakash Hospital / Maulana Azad Medical College, New Delhi. Pa kafukufukuyu, odwala 193 omwe amapezeka ndi osteoarthritis a bondo adasinthidwa kuti alandire chotulutsa turmeric (BCM-95) ngati kapisozi wa 500 mg kawiri tsiku lililonse, kapena piritsi la 650 mg la paracetamol katatu patsiku kwa milungu isanu ndi umodzi.

Zizindikiro zamatenda am'mimba zam'mimba, kuuma kwamagulu, komanso kuchepa kwa magwiridwe antchito adayesedwa pogwiritsa ntchito Western Ontario ndi McMaster Universities Osteoarthritis Index (WOMAC). Pambuyo pa chithandizo cha milungu isanu ndi umodzi, kuwunika kwa omwe adayankha kunawonetsa kusintha kwakukulu pamanambala a WOMAC m'magawo onse ofanana ndi gulu la paracetamol, pomwe 18% ya gulu la BCM-95 lipoti kusintha kwa 50%, ndi 3% ya maphunziro akuwona kusintha kwa 70%.

Zotsatirazi zidawonetsedwa bwino m'magulu a BCM-95 a seramu yotupa: Ma CRP adachepetsedwa ndi 37.21%, ndipo milingo ya TNF-α idadulidwa ndi 74.81%, kuwonetsa kuti BCM-95 idachita bwino kuposa paracetamol.

Kafukufukuyu anali kutsatira kafukufuku wa Arjuna wopitilira chaka chapitacho yemwe adawonetsa kulumikizana kwabwino pakati pamapangidwe ake a curcumin ndi chisamaliro cha osteoarthritic.

"Cholinga cha kafukufuku wapano chinali kukhazikitsa maphunziro am'mbuyomu kuti apereke tanthauzo lomveka bwino polemba zikwangwani zambiri komanso njira zowerengera bwino," atero a Benny Antony, director director a Arjuna. "Mphamvu yotsutsana ndi matenda a nyamakazi ya BCM-95 mu nyamakazi ya nyamakazi akuti imatha kupanga zikwangwani zotsutsana ndi zotupa za TNF ndi CRP."

Knee OA ndi yomwe imayambitsa kulumala komanso kupweteka pakati pa anthu okalamba komanso okalamba. Akuti pafupifupi 10 mpaka 15% ya achikulire onse azaka zopitilira 60 ali ndi digirii ya OA, yomwe imafala kwambiri pakati pa akazi kuposa amuna.

"Kafukufukuyu akutsimikiziranso kuti anti-arthitic zotsatira za BCM-95 ndikupereka chiyembekezo chatsopano kwa mamiliyoni kuti atukule moyo wawo," atero a Nipen Lavingia, mlangizi wazinthu zatsopano ku Arjuna Natural ku Dallas, TX.

"Tikuphunzira zambiri za njira zomwe zimapangitsa kuti curcumin azitsutsana ndi zotupa zomwe timakhulupirira kuti ndi chifukwa chakuletsa kwake ma sign-pro-inflammatory, monga ma prostaglandins, leukotrienes, ndi cyclooxygenase-2. Kuphatikiza apo, curcumin yawonetsedwa kuti ichepetsa ma cytokines angapo opatsirana komanso otetezera kumasulidwa kwawo, monga chotupa necrosis factor-α (TNF-α), IL-1, IL-8, ndi nitric oxide synthase, "atero Antony.

Kusakanikirana kwapadera kwa BCM-95 kwama curcuminoids ndi mafuta opangira turmerone omwe amapindulitsa mafuta amathetsa zovuta za curcumin zomwe zimayambitsa zovuta chifukwa chokhala ndi lipophilic.


Post nthawi: Apr-12-2021